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Trifexis 6pk Dog 5-10 lbs product detail number 1.0

At a Glance

Choose the Trusted, Triple Parasite Protection of Trifexis (spinosad + milbemycin oxime)
Protect your patients from heartworm disease, fleas and intestinal parasites with Trifexis
Easy to administer, beef flavored tablet

Trifexis

Trifexis - Flea, Heartworm, + Broad Spectrum Prevention Chewable Tablet for Dogs

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Prescription required.

Learn more

Save $73 by joining PetPlus

Prescription Required

At a Glance

Choose the Trusted, Triple Parasite Protection of Trifexis (spinosad + milbemycin oxime)
Protect your patients from heartworm disease, fleas and intestinal parasites with Trifexis
Easy to administer, beef flavored tablet

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About this product

1. What Is Trifexis?

Answer

Trifexis is a prescription drug used to prevent and treat flea infestations, heartworm disease, and certain intestinal parasites in dogs. It is a once-monthly chewable tablet used to treat and manage some types of intestinal parasites, such as hookworms, roundworms, and whipworms, as well as to eradicate fleas and stop flea infestations.

2. What Are the Active Components of Trifexis?

Answer

The active ingredients in Trifexis are spinosad and milbemycin oxime. Spinosad is a pesticide that kills fleas by attacking their nervous system. On the other hand, Milbemycin oxime is an antiparasitic medicine that prevents heartworm disease by destroying young heartworm larvae (microfilariae) and certain forms of intestinal parasites (hookworms, roundworms, and whipworms) by interfering with their nervous system and muscular activity.

3. Can Trifexis Be Used on Puppies?

Answer

Trifexis for puppies is approved for use in only puppies that are already 8 weeks of age and weigh at least 5 pounds. It is important to consult with a veterinarian before administering Trifexis to a puppy, as the dosage may need to be adjusted based on the puppy's weight.

4. Can Trifexis Be Used on Pregnant or Nursing Dogs?

Answer

Use of Trifexis in canines that are either pregnant or lactating is not recommended. The prescribing information for Trifexis states, "The safety of Trifexis in breeding, pregnant, or lactating dogs has not been evaluated. Use with caution in dogs with pre-existing epilepsy." Some studies have reported adverse effects in puppies born to mothers who received Trifexis during pregnancy or nursing, including loss of litter, vomiting, and poor weight gain.

5. What Are the Possible Side Effects of Trifexis?

Answer

The most common side effects reported with Trifexis are vomiting, diarrhea, reduced appetite, and unexplainable weakness. In rare cases, dogs may experience more severe reactions, such as seizures, hypersensitivity reactions (hives, itching, and swelling), or neurologic signs (such as ataxia or muscle tremors).

6. Can Trifexis Be Given Alongside Other Medications?

Answer

Certain medications may interact with Trifexis or affect its efficacy. For example, medications that increase the metabolism of milbemycin (one of the active ingredients in Trifexis) may reduce its effectiveness. Additionally, medications that affect liver function may affect the metabolism of spinosad (the other active ingredient in Trifexis). As such, it is important to consult a vet before using Trifexis alongside other drugs.

7. Is Trifexis Effective Against All Types of Worms?

Answer

Trifexis for small dogs is effective against many intestinal parasites, including roundworms, hookworms, and whipworms. However, it does not work against all types of worms. Trifexis does not protect against tapeworms or lungworms, other common worms that can infect dogs.

8. What Is the Cost of Trifexis?

Answer

On average, Trifexis can cost between $100 and $200 for a six-month supply, but prices may be higher or lower depending on your location and other factors.

9. How Long Does Trifexis Take To Take Effect?

Answer

Trifexis starts functioning right away to eliminate fleas and stop flea infestations. However, the precise amount of time it takes to start working might change depending on the kind of parasite. According to the manufacturer's information, Trifexis begins killing fleas within 30 minutes of administration and can kill 100% of fleas within 4 hours. It also begins working to prevent heartworm disease immediately after administration.

10. What Should I Do if My Pet Misses a Trifexis Dose?

Answer

It is best to give the missed dose with food as soon as it is remembered and then continue with the regular monthly dosing schedule from that date. Do not give extra or double Trifexis doses, as this can increase the risk of side effects and may not provide any additional benefit.

11. How Should Trifexis Be Stored?

Answer

Trifexis should be kept at room temperature (68–77°F or 20–25°C), dry, and cold. It should be stored out of reach of children and animals and preserved in its original packaging.

12. Can Trifexis Be Used on All Dog Breeds?

Answer

Trifexis has been extensively studied and demonstrated to be safe and effective in pure and mixed breed dogs that are at least 8 weeks of age and weigh at least 5 pounds when used according to the label directions. These studies have been conducted on various dog breeds, including purebred and mixed breed dogs, and have shown that Trifexis is generally well-tolerated and effective in preventing flea infestations, heartworm disease, and certain types of intestinal parasites.

13. Can Trifexis Be Used on Cats?

Answer

No, Trifexis is not approved for use in cats. Trifexis should not be administered to cats or other animals because it is designed primarily for use in dogs. Using Trifexis for cats can result in adverse complications, affecting your cat’s health.

14. Can Trifexis Be Purchased Without a Prescription?

Answer

Trifexis must be acquired with a prescription from an authorized veterinarian because it is a prescription drug. The active ingredients in Trifexis, spinosad, and milbemycin oxime, are classified as prescription drugs by the FDA and can only be dispensed by a licensed veterinarian or pharmacy with a valid prescription.

What is Trifexis® (spinosad + milbemycin oxime)?

Trifexis (spinosad + milbemycin oxime) is the monthly, beef-flavored tablet prescribed to kill fleas and prevent flea infestations, prevent heartworm disease, and treat and control adult hookworm, roundworm and whipworm infection in dogs. Trifexis requires a prescription from your veterinarian.

For:

Dogs (8+ weeks of age, weighing 5+ lbs)

Benefits:

Choose the Trusted, Triple Parasite Protection of Trifexis (spinosad + milbemycin oxime)
Protect your patients from heartworm disease, fleas and intestinal parasites with Trifexis
Easy to administer, beef flavored tablet

How does Trifexis work?

Spinosad, an active ingredient in Trifexis, starts to work within 30 minutes to kill fleas and has been proven to kill 100% of all biting fleas within 4 hours. Trifexis prevents heartworm disease by killing microfilariae and larvae from maturing into adult heartworms.

Cautions:

Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis chewable tablets. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. Puppies less than 14 weeks of age may experience a higher rate of vomiting. Consult your veterinarian for pregnant or lactating dogs.

Brand Name:

Trifexis (Elanco Animal Health)

Generic Name:

Spinosad and Milbemycin oxime

What is the most important thing I should know about Trifexis?

Trifexis is a prescription medication FDA approved for use in dogs 8 weeks of age or older and 5 lbs of body weight or more. Trifexis contains spinosad and milbemycin oxime and is indicated for the prevention of heartworm disease. Trifexis kills fleas and is indicated for the prevention and treatment of flea infestations, and the treatment and control of adult hookworm, adult roundworm, and adult whipworm infections. Trifexis is available in a Pink box for dogs 5 to 10 lbs (140 mg/2.3 mg), Orange box for dogs 10.1 to 20 lbs (270 mg/4.5 mg), Green box for dogs 20.1 to 40 lbs (560 mg/9.3 mg), Blue box for dogs 40.1 to 60 lbs (810 mg/13.5 mg), and Brown box for dogs 60.1 to 120 lbs (1620 mg/27 mg). For dogs over 120 lbs, give the appropriate combination of tablets.

What should I discuss with my veterinarian before giving Trifexis to my pet?

Tell your veterinarian if you are planning on breeding your pet. Tell your veterinarian if your dog has a history of seizures (epilepsy).

How should Trifexis be given?

Give Trifexis chewable tablets once a month with food. Trifexis chewable tablets may be chewed, offered in food, or administered like other tablet medications. If vomiting occurs within 1 hour of administration, redose your pet with another full dose. Consult your veterinarian for pregnant or lactating dogs.

What are the potential side effects of Trifexis?

Side effects that may occur include vomiting. If vomiting occurs within one hour of administration, redose with another full dose. Other side effects may occur. Continue giving Trifexis chewable tablets and talk to your veterinarian if your pet experiences decreased appetite, lethargy or decreased activity, diarrhea, cough, increased thirst, vocalization, increased appetite, itching, hyperactivity. Talk to your veterinarian about any side effect that seems unusual or especially bothersome to your pet. The use of ivermectin at higher than FDA-approved doses at the same time as Trifexis can result in serious side effects.

What happens if I miss giving a dose of Trifexis?

Give the missed dose with food as soon as you remember and resume a monthly dosing schedule.

What happens if I overdose my pet on Trifexis?

Overdose of this medication is unlikely. However, if an overdose is suspected, contact your veterinarian or veterinary emergency room. Symptoms of overdose that may occur include vomiting.

What should I avoid while giving Trifexis to my pet?

Your pet may maintain normal activities and interactions while being given Trifexis. The safe use of Trifexis chewable tablets in male dogs intended for breeding has not been established.

What other drugs will affect Trifexis?

Talk to your veterinarian before giving any prescription or over the counter medications.

Trifexis Directions:

Trifexis is given orally, once a month. Administer Trifexis with food for maximum effectiveness. Please view the chart below for the correct dosage of Trifexis for your dog.

Tip:

Always provide fresh drinking water.

Trifexis Dosage for Dogs (8+ weeks of age, weighing 5+ lbs)

Dogs (8+ weeks of age, weighing 5+ lbs)
Weight	Dosage
5-10 lbs	Give one tablet (Pink box)
10.1-20 lbs	Give one tablet (Orange box)
20.1-40 lbs	Give one tablet (Green box)
40.1-60 lbs	Give one tablet (Blue box)
60.1-120 lbs	Give one tablet (Brown box)
Over 120 lbs	Administer the appropriate combination of tablets

Trifexis Dosage for Cats:
Cats
Do not use!

Trifexis Dosage for Horses:
Horses
Do not use!

Storage:

Store Trifexis at room temperature (68°-77° F). Keep out of the reach of children.

Trifexis Ingredients:

Trifexis Pink box (5-10 lbs):
Active Ingredients per tablet	Amount
Spinosad	140 mg
Milbemycin oxime	2.3 mg

Trifexis Orange box (10.1-20 lbs):
Active Ingredients per tablet	Amount
Spinosad	270 mg
Milbemycin oxime	4.5 mg

Trifexis Green box (20.1-40 lbs):
Active Ingredients per tablet	Amount
Spinosad	560 mg
Milbemycin oxime	9.3 mg

Trifexis Blue box(40.1-60 lbs):
Active Ingredients per tablet	Amount
Spinosad	810 mg
Milbemycin oxime	13.5 mg

Trifexis Brown box(60.1-120 lbs):
Active Ingredients per tablet	Amount
Spinosad	1620 mg
Milbemycin oxime	27 mg

Product Details

What is Trifexis® (spinosad + milbemycin oxime)?

For:

Dogs (8+ weeks of age, weighing 5+ lbs)

Benefits:

Choose the Trusted, Triple Parasite Protection of Trifexis (spinosad + milbemycin oxime)
Protect your patients from heartworm disease, fleas and intestinal parasites with Trifexis
Easy to administer, beef flavored tablet

How does Trifexis work?

Cautions:

Brand Name:

Trifexis (Elanco Animal Health)

Generic Name:

Spinosad and Milbemycin oxime

What is the most important thing I should know about Trifexis?

What should I discuss with my veterinarian before giving Trifexis to my pet?

Tell your veterinarian if you are planning on breeding your pet. Tell your veterinarian if your dog has a history of seizures (epilepsy).

How should Trifexis be given?

What are the potential side effects of Trifexis?

What happens if I miss giving a dose of Trifexis?

Give the missed dose with food as soon as you remember and resume a monthly dosing schedule.

What happens if I overdose my pet on Trifexis?

Overdose of this medication is unlikely. However, if an overdose is suspected, contact your veterinarian or veterinary emergency room. Symptoms of overdose that may occur include vomiting.

What should I avoid while giving Trifexis to my pet?

Your pet may maintain normal activities and interactions while being given Trifexis. The safe use of Trifexis chewable tablets in male dogs intended for breeding has not been established.

What other drugs will affect Trifexis?

Talk to your veterinarian before giving any prescription or over the counter medications.

How to use

Trifexis Directions:

Trifexis is given orally, once a month. Administer Trifexis with food for maximum effectiveness. Please view the chart below for the correct dosage of Trifexis for your dog.

Tip:

Always provide fresh drinking water.

Trifexis Dosage for Dogs (8+ weeks of age, weighing 5+ lbs)

Dogs (8+ weeks of age, weighing 5+ lbs)
Weight	Dosage
5-10 lbs	Give one tablet (Pink box)
10.1-20 lbs	Give one tablet (Orange box)
20.1-40 lbs	Give one tablet (Green box)
40.1-60 lbs	Give one tablet (Blue box)
60.1-120 lbs	Give one tablet (Brown box)
Over 120 lbs	Administer the appropriate combination of tablets

Trifexis Dosage for Cats:
Cats
Do not use!

Trifexis Dosage for Horses:
Horses
Do not use!

Storage:

Store Trifexis at room temperature (68°-77° F). Keep out of the reach of children.

Ingredients

Trifexis Ingredients:

Trifexis Pink box (5-10 lbs):
Active Ingredients per tablet	Amount
Spinosad	140 mg
Milbemycin oxime	2.3 mg

Trifexis Orange box (10.1-20 lbs):
Active Ingredients per tablet	Amount
Spinosad	270 mg
Milbemycin oxime	4.5 mg

Trifexis Green box (20.1-40 lbs):
Active Ingredients per tablet	Amount
Spinosad	560 mg
Milbemycin oxime	9.3 mg

Trifexis Blue box(40.1-60 lbs):
Active Ingredients per tablet	Amount
Spinosad	810 mg
Milbemycin oxime	13.5 mg

Trifexis Brown box(60.1-120 lbs):
Active Ingredients per tablet	Amount
Spinosad	1620 mg
Milbemycin oxime	27 mg

Q&A

1. What Is Trifexis?

Answer

2. What Are the Active Components of Trifexis?

Answer

3. Can Trifexis Be Used on Puppies?

Answer

4. Can Trifexis Be Used on Pregnant or Nursing Dogs?

Answer

5. What Are the Possible Side Effects of Trifexis?

Answer

6. Can Trifexis Be Given Alongside Other Medications?

Answer

7. Is Trifexis Effective Against All Types of Worms?

Answer

8. What Is the Cost of Trifexis?

Answer

On average, Trifexis can cost between $100 and $200 for a six-month supply, but prices may be higher or lower depending on your location and other factors.

9. How Long Does Trifexis Take To Take Effect?

Answer

10. What Should I Do if My Pet Misses a Trifexis Dose?

Answer

11. How Should Trifexis Be Stored?

Answer

Trifexis should be kept at room temperature (68–77°F or 20–25°C), dry, and cold. It should be stored out of reach of children and animals and preserved in its original packaging.

12. Can Trifexis Be Used on All Dog Breeds?

Answer

13. Can Trifexis Be Used on Cats?

Answer

14. Can Trifexis Be Purchased Without a Prescription?

Answer

Based on 0 reviews

Yara

Works well, Dog doesn't like

This medication does it's job! Unfortunately, our picky Pomeranian hates the taste, so we have to crush it up and give it to her with something else, like cheese.

Would recommend this product

Helpful?

MomOfDoodlesDog

So Easy!

Combining Flea & Heartworm med in one pill is easier & less expensive!

Would recommend this product

Helpful?

Lola's Mom

Perfect

My long hair chihuahua was having a terrible time last summer with fleas because it didn't get cold the previous winter. Fleas were terrible last summer and nothing got rid of the problem. She's a senior lady only weighing 7 lbs so I'm very cautious what to use on her. Tried the Trifexis and that did the trick. In the fall we switched back to Heartguard, she loves the taste. We will see how the fleas are this coming summer (it got unusually cold last winter) but won't hesitate to use the Trifexis if needed.

Would recommend this product

Helpful?

RaccoonMom

~Me C No Fleas!~

An excellent product that takes care of most parasites, especially appreciated here in SW FL. No fleas-No tape worms, either.

Would recommend this product

Helpful?

Pam

Happy2B

Awesome service with great prices. Bella is better off with PetCareRx!

Would recommend this product

Helpful?

Linda Johnson

Its great

I have not had any issues with this product and my girl has been using Trifexis for 2 years now the only thing is I have to crush it up for my girl and mix it with coconut oil for her to take it but other then that she is flea and heartworm free for 2 years now.