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Tri-Heart Plus 6pk Blue 1-25 lbs product detail number 1.0 10411 10411 10411 10411
At a Glance
  • Contains the same active ingredients, ivermectin/pyrantel, as the leading competitor, but at a lower price.
  • Prevents heartworm disease, treats, and controls roundworms and hookworms.
  • Kills heartworm larvae before they reach your dog’s heart. 
  • Enjoy year-round protection for your dog, with monthly treatments.
  • Easy-to-give, beef-flavored, chewable tablet that your dog will enjoy.
  • 94% of dogs love the chewable tablets. In a taste test, dogs proved to have no preference for Tri-Heart Plus®; & HEARTGARD®.
  • Safe for dogs with beef allergies.
Tri-Heart Plus

Triheart Plus - Heartworm, Hookworm, Roundworm Prevention Chewable Tablet for Dogs

Just as effective, just as palatable! The same proven active ingredients as the leading heartworm preventative brand.
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Tri-Heart Plus 6pk Blue 1-25 lbs product detail number 1.0 10411 10411 10411 10411

* Recommended by our Veterinarian Advisory Board

At a Glance
  • Contains the same active ingredients, ivermectin/pyrantel, as the leading competitor, but at a lower price.
  • Prevents heartworm disease, treats, and controls roundworms and hookworms.
  • Kills heartworm larvae before they reach your dog’s heart. 
  • Enjoy year-round protection for your dog, with monthly treatments.
  • Easy-to-give, beef-flavored, chewable tablet that your dog will enjoy.
  • 94% of dogs love the chewable tablets. In a taste test, dogs proved to have no preference for Tri-Heart Plus®; & HEARTGARD®.
  • Safe for dogs with beef allergies.
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About this product
1. What Does Tri-Heart Plus Cover?
Answer
Tri-Heart Plus is a chewable tablet that is effective against heartworms and other hazardous parasites. Dogs can get infected with hookworms, roundworms, or heartworms at any point in life. Tri-Heart Plus is formulated with a tested combination of Ivermectin and Pyrantel to protect your dogs from these parasites. Tri-Heart Plus chewable tablets effectively prevent heartworms in dogs triggered by Dirofilaria immitis. The tablet is also effective in controlling and treating Ascarids and hookworms in canines and also six-week-old pups.
2. Are Triheart and Heartgard the Same?
Answer
It is surprising to know that both the top-line medicines are very similar when compared to their differences. The similarities are because of the two main ingredients in their making (Ivermectin and Pyrantel Pamoate). The similarity in ingredients makes them equally effective in preventing heartworms and treating roundworms and hookworms. Both Heartgard Plus and Tri-Heart Plus are available only on a veterinarian prescription. The dosage is also the same and given once every month. Both the medications are safe for breeding and pregnant dogs. The minimum age of puppies should be at least six weeks or more for administering both medicines. However, with all these similarities, the medications still have two key differences. The first difference is that Tri-Heart Plus is a beef-flavored chewable tablet, whereas Heartgard Plus is a soft beefy chew. The second difference is the rates; Tri-Heart Plus is much cheaper than Heartgard Plus, making the former a preferred choice.
3. Does Tri-Heart Plus Need to be Given with Food?
Answer
The effective dosage of Tri-Heart Plus is once every month or as per the dosage prescribed by your veterinarian. You can give the tablet directly or can even mix it with your dog’s routine food. It totally depends on how comfortable your dog is with taking these chewable tablets. However, the Tri-Heart Plus tablets come in beef flavor, and most dogs just eat it like some treat. We must ensure that the dosage is regular and once every month to protect your dog by eliminating any growing larva before it reaches your dog’s heart.
4. How Long is Tri-Heart Plus Good For?
Answer
Tri-Heart Plus is good for 30 days only. Hence, be sure to repeat the dosage immediately after a month. If you have missed a dose, give it as soon as you realize it and continue monthly. If the missed dose is over by two weeks, your dog must undergo microfilariae and antigen tests in 6 months. Repeat the tests in 6 months, as sometimes the results are not visible in the initial 6-month heartworm test. Because of its effectiveness of 30 days, you should set reminders for medication so that you do not miss any dose.
5. Does Tri-Heart Plus Prevent Tapeworms?
Answer
A simple answer to this can be a Yes. The monthly dosage of Tri-Heart Plus is capable of doing a lot more than preventing heartworm diseases. The medication can also control intestinal parasites like tapeworms, whipworms, hookworms, and roundworms. The only thing to remember is a regular dosage every 30 days and without skipping any dosage.
6. Can I Give My Dog Expired Tri-Heart Plus?
Answer
Any medication that includes Tri-heart Plus, which has reached its expiry date, should not be administered on pets. Tri-Heart Plus is only effective when used within its expiration date and when stored as mentioned on the medicine pack. The expiration date specifies that the active ingredients (Ivermectin and Pyrantel Pamoate) will not work effectively beyond the date.
7. What's the Difference between Tri-Heart Plus and Heartgard Plus?
Answer
There are two main differences between Tri-Heart Plus and Heartgard Plus. The first difference is that Tri-Heart Plus comes as a beef-flavored chewable tablet, whereas Heartgard Plus is a soft beefy chew. The second difference is the price; Tri-Heart Plus is much cheaper than Heartgard Plus, making the former a preferred choice.
8. What is the Difference between Trifexis and Tri-Heart Plus?
Answer
The main difference between the two medications is their active ingredients. While Tri-Heart Plus has Ivermectin and Pyrantel Pamoate, Trifexis contains Spinosad and Milbemycin Oxime. Other differences include the minimum dosage age, which is six weeks for Tri-Heart Plus, while it is eight weeks and 6 lbs of weight for Trifexis. Tri-Heart Plus is safe for breeding and pregnant dogs, but Trifexis is not yet proven for safety in pregnant, breeding, and lactating dogs. Trifexis provides extra protection from other hazardous parasites like fleas and whipworms, which cannot be said for Tri-Heart Plus.
9. Does Tri Heart Plus Require a Prescription?
Answer
Yes, it is mandatory to have a prescription to buy Tri-Heart Plus chewable tablets. You can consult your veterinarian about the same and get them prescribed for your pet dog.
10. When should I start heartworm prevention for my dog?
Answer
It is recommended to start heartworm prevention for your dog as early as possible, ideally before they are six months old. However, if your dog is older than six months and has not been on heartworm prevention, it is still necessary to start them on a preventative medication as soon as possible. Heartworm prevention medication is typically given monthly, and it is important to give it consistently throughout the year to ensure that your dog remains protected. Your veterinarian can recommend the most appropriate heartworm prevention medication for your dog based on age, weight, and other individual factors. In addition to giving your dog heartworm prevention medication, also have them tested for heartworms annually, even if they are on a preventative medication. This will ensure that any potential heartworm infection is detected early and can be treated before it becomes a serious health issue for your dog.
11. What are the signs of heartworms in dogs?
Answer
Heartworm disease in dogs can present with a variety of symptoms, which can vary depending on the severity of the infection. In the early stages of the disease, there may be no visible symptoms at all. A persistent cough is one of the most common signs of heartworm disease in dogs. The cough may be dry or may produce a small amount of phlegm. Dogs with heartworm disease may be less active than usual and may tire easily during exercise or play. Dogs with heartworm disease may lose their appetite or have difficulty eating. This can lead to weight loss and muscle wasting. As the heartworms grow and multiply in the lungs and heart, they can make it difficult for your dog to breathe. This can result in shortness of breath, rapid breathing, or wheezing. In advanced cases of heartworm disease, the heart and lungs may become so compromised that fluid accumulates in the abdomen. This can lead to a swollen belly or distended abdomen. Dogs with heartworm disease may have a dull, rough, or dry coat, which can be a sign of poor health. Some dogs may develop an allergic reaction to heartworms, which can cause skin irritation, hives, or other symptoms. In severe cases of heartworm disease, dogs may experience collapse or fainting. This can be a life-threatening emergency. In rare cases, heartworm disease can lead to bleeding problems, including nosebleeds, blood in the urine or stool, or excessive bleeding from wounds.
12. Is there natural heartworm prevention?
Answer
While there are some natural remedies that are sometimes suggested for heartworm prevention in dogs, it's important to note that there is no scientifically proven natural heartworm prevention method. Heartworm disease is a serious and potentially life-threatening condition, and the most effective way to prevent it is through the use of prescription heartworm prevention medication that has been tested and approved by the FDA. These medications work by killing the immature heartworms that are transmitted to dogs through mosquito bites, preventing them from developing into adult heartworms that can cause serious health problems. That being said, some people believe that adding garlic to a dog's diet can help to repel mosquitoes and reduce the risk of heartworm infection. However, garlic can actually be toxic to dogs in large amounts. Another natural remedy that is sometimes suggested for heartworm prevention in dogs is apple cider vinegar. Advocates claim that adding small amounts of apple cider vinegar to a dog's food or water can make their skin less attractive to mosquitoes, thus reducing the risk of heartworm infection. Some people suggest using neem oil as a natural mosquito repellent for dogs, which may help to reduce the risk of heartworm infection. However, neem oil can be toxic if ingested in large amounts, so it should be used with caution. Some herbal supplements, such as black walnut, wormwood, and clove, are sometimes recommended as natural heartworm preventatives for dogs. But none of these natural remedies have been scientifically proven to prevent heartworm disease in dogs, and relying solely on these methods may put your dog at risk of serious health problems.
13. Is heartworm treatment lifelong?
Answer
Heartworm treatment is a process used to eliminate adult heartworms that have already developed in a dog's body. The treatment typically involves a series of injections that are administered over several months, along with strict rest and exercise restrictions. Once the adult heartworms have been eliminated, it's necessary to continue with a preventative care plan to prevent re-infection. On the other hand, heartworm prevention refers to the regular use of prescription medication to prevent heartworms from developing in a dog's body in the first place. These medications are typically administered on a monthly basis and work by killing any immature heartworms that may have been transmitted to your dog through mosquito bites. While heartworm treatment is a temporary process that lasts several months, heartworm prevention is an ongoing process that requires regular administration of preventative medication.
14. How long can a dog go without heartworm pills?
Answer
Some monthly heartworm prevention medications have a "grace period" or "safety factor" of a few days to a couple of weeks, which means that missing a single dose may not immediately put your dog at risk of heartworm infection. However, missing even a single dose of heartworm prevention medication can increase the risk of heartworm infection, and a regular, consistent administration of preventative medication is the best way to ensure that your dog remains healthy and heartworm-free. If you do miss a dose of heartworm prevention medication, it's best to contact your veterinarian for advice on how to proceed.
15. What ingredient kills heartworms?
Answer
The active ingredient that kills heartworms in most prescription heartworm prevention medications is called ivermectin. Ivermectin works by targeting the immature heartworms (microfilariae) that are transmitted to dogs through mosquito bites, preventing them from developing into adult heartworms that can cause serious health problems. Other prescription heartworm prevention medications may contain different active ingredients, such as milbemycin oxime, selamectin, or moxidectin, which also work to prevent heartworm infection by targeting immature heartworms. You should note that prescription heartworm prevention medications, including those containing ivermectin, milbemycin oxime, selamectin, or moxidectin, are designed to prevent the development of heartworms in their early stages when they are still immature microfilariae. These medications do not work on adult heartworms, which have already developed in a dog's body. To eliminate adult heartworms, a different treatment process involving a series of injections over several months is required. That's why it's crucial to follow your veterinarian's recommended preventative care plan and schedule regular check-ups to ensure that your dog remains healthy and heartworm-free.

What is Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets?

Tri-Heart Plus® (ivermectin/pyrantel) chewable tablets are indicated for use in prevention of canine heartworm caused by Dirofilaria immitis and for the treatment and control of ascarids (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense) in dogs and in puppies six weeks of age.

Suitable for:

Dogs and Puppies (6+ weeks of age)

Benefits:

  • Contains the same active ingredients, ivermectin/pyrantel, as the leading competitor, but at a lower price.
  • Prevents heartworm disease, treats, and controls roundworms and hookworms.
  • Kills heartworm larvae before they reach your dog’s heart. 
  • Enjoy year-round protection for your dog, with monthly treatments.
  • Easy-to-give, beef-flavored, chewable tablet that your dog will enjoy.
  • 94% of dogs love the chewable tablets. In a taste test, dogs proved to have no preference for Tri-Heart Plus®; & HEARTGARD®.
  • Safe for dogs with beef allergies.
  • Available in three dosage strengths for dogs of different weights.

How do Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets work?

Tri-Heart Plus® is a proven, cost-effective and easy-to-administer chewable tablet that helps keep your dog free of heartworm and other dangerous parasites. Tri-Heart Plus® chewable tablets contain a proven combination of ingredients to protect your dog and ensure your complete peace of mind. Ask your veterinarian about Tri-Heart Plus® today.

Cautions:

The following adverse reactions have been reported following the use of ivermectin at the recommended dose: depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation. All dogs should be tested for heartworm infection before starting a preventive program. In a small percentage of ivermectin/pyrantel treated dogs, digestive and neurological side effects may occur.

Brand Name:

Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets

Generic Name:

Ivermectin, Pyrantel

What is the most important thing I should know about Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets?

The most important thing to know about Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets is that it is a combination medication used to prevent heartworm disease and treat and control roundworm and hookworm infections in dogs. The active ingredients, ivermectin and pyrantel, work together to kill heartworm larvae before they mature and to treat intestinal worms. It's crucial to administer this medication according to the prescribed schedule (usually once a month) to maintain its effectiveness. Additionally, a dog should be tested for existing heartworm infection before starting the medication, as severe adverse reactions can occur if administered to a heartworm-positive dog. Always consult with a veterinarian before starting or changing any medication regimen for your pet.

What should I discuss with my veterinarian before giving Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets to my pet?

Always consult with a veterinarian before starting or changing any medication regimen for your pet.

  • Heartworm Testing: Ensure your dog has been tested for heartworms. Administering Tri-Heart Plus® to a dog that is already infected with heartworms can lead to severe adverse reactions.
  • Breed Sensitivities: Some dog breeds, particularly Collies and related breeds, may have a genetic sensitivity to ivermectin. Discuss your dog's breed and any potential risks associated with ivermectin sensitivity.
  • Current Medications: Inform your veterinarian about any other medications or supplements your dog is currently taking, as there could be interactions or contraindications.
  • Health History: Discuss your dog's overall health, including any history of illnesses or allergies, as this can 

How should Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets be given?

Tri-Heart Plus®; Plus should be administered orally at monthly intervals during the period of the year when mosquitoes
(vectors), potentially carrying infective heartworm larvae, are active at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes. The final dose must be given
within a month (30 days) after the dog’s last exposure to mosquitoes.

What are the potential side effects of Tri-Heart Plus® (ivermectin/pyrantel)Chewable Tablets?

Side effects of Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets are rare at the recommended heartworm prevention dose, but may include lethargy, limpness, salivation, shaking, diarrhea, decreased appetite, licking lips, and belching. Higher doses in dogs may cause tremors, dilated pupils, loss of body weight, or death.

What happens if I miss giving a dose of Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets?

If the interval between doses exceeds 30 days, the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable tablet must be given once a month, on or about the same day of the month. If treatment is delayed, whether by a few days or many, please contact your veterinarian, as immediate treatment with Tri-Heart Plus® chewable tablets and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.

What happens if I overdose my pet on Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets?

Contact your veterinarian immediately if accidental overdose occurs. To reduce the risk of accidental overdose in situations where more than one person may administer Tri-Heart Plus®, we suggest ticking off the date on a specially marked calendar or making some other note to indicate that the dose has been given. Make a habit of checking with the other pet caregivers in your household before giving any medications to your pet.

What should I avoid while giving Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets to my pet?

Do not administer Tri-Heart Plus® if your dog has not been tested for heartworms or if the test results are positive. This can cause severe reactions due to the presence of mature heartworms. Do not use Tri-Heart Plus® past its expiration date. The effectiveness of the medication may decrease, and it could be harmful to your dog. Some breeds, like Collies and other herding breeds, may have a genetic sensitivity to ivermectin. Avoid giving the medication to these breeds without consulting your veterinarian.

What other drugs will affect Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets?

Avoid giving your dog any other medications, especially those containing ivermectin or similar compounds, without consulting your veterinarian to prevent potential drug interactions.

Storage

Store at controlled room temperatures of 59° - 86°F. Protect product from light.

See more

Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets Directions:

  • Give your dog one beef-flavored chewable Tri-Heart Plus® tablet on the same day each month during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active, at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. 
  • Remove only one chewable tablet at a time from the blister card. Because most dogs find Tri-Heart Plus® palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dry food or placed in the back of the dog’s mouth for forced swallowing.
  • Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.
  • The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog’s last exposure to mosquitoes.
  • The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms can be found in the table below.

Tip:

Incorporate the administration of Tri-Heart Plus® into a positive, routine activity that your dog enjoys, such as a monthly "spa day" or special treat time. For example, you can pair giving the tablet with a favorite treat, a fun grooming session, or a playtime ritual. This creates a positive association with taking the medication, making it easier for your dog to accept the tablet willingly each month. Additionally, by integrating the medication into a routine event, you're less likely to forget a dose, ensuring consistent heartworm and parasite prevention.

TRI-HEARTTri-Heart Plus® PLUS (ivermectin/pyrantel) Chewable Tablets Dosage

Dosage for Dogs & Puppies: (6+ weeks of age)
Weight Dosage Ivermectin Content Pyrantel Content Color Coding on Box
Up to 25 lbs Give 1 chewable every month 68 mcg 57 mg Blue Box
26-50 lbs Give 1 chewable every month 136 mcg 114 mg Green Box
51-100 lbs Give 1 chewable every month 272 mcg 227 mg Brown Box
Over 100 lbs Give combination of chewables based on weight See packaging See packaging See packaging
Dosage for Cats:
Cats
Do not use!
Dosage for Horses:
Horses
Do not use!

Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets Ingredients:

Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets - Blue Box (Dogs up to 25 lbs):
Active Ingredients (per chewable tablet) Amount
Ivermectin 68 mcg
Pyrantel 57 mg
Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets - Green Box (Dogs 26-50 lbs):
Active Ingredients (per chewable tablet) Amount
Ivermectin 136 mcg
Pyrantel 114 mg
Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets - Brown Box (Dogs 51-100 lbs):
Active Ingredients (per chewable tablet) Amount
Ivermectin 272 mcg
Pyrantel 227 mg
Product Details
plus minus

What is Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets?

Tri-Heart Plus® (ivermectin/pyrantel) chewable tablets are indicated for use in prevention of canine heartworm caused by Dirofilaria immitis and for the treatment and control of ascarids (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense) in dogs and in puppies six weeks of age.

Suitable for:

Dogs and Puppies (6+ weeks of age)

Benefits:

  • Contains the same active ingredients, ivermectin/pyrantel, as the leading competitor, but at a lower price.
  • Prevents heartworm disease, treats, and controls roundworms and hookworms.
  • Kills heartworm larvae before they reach your dog’s heart. 
  • Enjoy year-round protection for your dog, with monthly treatments.
  • Easy-to-give, beef-flavored, chewable tablet that your dog will enjoy.
  • 94% of dogs love the chewable tablets. In a taste test, dogs proved to have no preference for Tri-Heart Plus®; & HEARTGARD®.
  • Safe for dogs with beef allergies.
  • Available in three dosage strengths for dogs of different weights.

How do Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets work?

Tri-Heart Plus® is a proven, cost-effective and easy-to-administer chewable tablet that helps keep your dog free of heartworm and other dangerous parasites. Tri-Heart Plus® chewable tablets contain a proven combination of ingredients to protect your dog and ensure your complete peace of mind. Ask your veterinarian about Tri-Heart Plus® today.

Cautions:

The following adverse reactions have been reported following the use of ivermectin at the recommended dose: depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation. All dogs should be tested for heartworm infection before starting a preventive program. In a small percentage of ivermectin/pyrantel treated dogs, digestive and neurological side effects may occur.

Brand Name:

Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets

Generic Name:

Ivermectin, Pyrantel

What is the most important thing I should know about Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets?

The most important thing to know about Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets is that it is a combination medication used to prevent heartworm disease and treat and control roundworm and hookworm infections in dogs. The active ingredients, ivermectin and pyrantel, work together to kill heartworm larvae before they mature and to treat intestinal worms. It's crucial to administer this medication according to the prescribed schedule (usually once a month) to maintain its effectiveness. Additionally, a dog should be tested for existing heartworm infection before starting the medication, as severe adverse reactions can occur if administered to a heartworm-positive dog. Always consult with a veterinarian before starting or changing any medication regimen for your pet.

What should I discuss with my veterinarian before giving Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets to my pet?

Always consult with a veterinarian before starting or changing any medication regimen for your pet.

  • Heartworm Testing: Ensure your dog has been tested for heartworms. Administering Tri-Heart Plus® to a dog that is already infected with heartworms can lead to severe adverse reactions.
  • Breed Sensitivities: Some dog breeds, particularly Collies and related breeds, may have a genetic sensitivity to ivermectin. Discuss your dog's breed and any potential risks associated with ivermectin sensitivity.
  • Current Medications: Inform your veterinarian about any other medications or supplements your dog is currently taking, as there could be interactions or contraindications.
  • Health History: Discuss your dog's overall health, including any history of illnesses or allergies, as this can 

How should Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets be given?

Tri-Heart Plus®; Plus should be administered orally at monthly intervals during the period of the year when mosquitoes
(vectors), potentially carrying infective heartworm larvae, are active at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes. The final dose must be given
within a month (30 days) after the dog’s last exposure to mosquitoes.

What are the potential side effects of Tri-Heart Plus® (ivermectin/pyrantel)Chewable Tablets?

Side effects of Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets are rare at the recommended heartworm prevention dose, but may include lethargy, limpness, salivation, shaking, diarrhea, decreased appetite, licking lips, and belching. Higher doses in dogs may cause tremors, dilated pupils, loss of body weight, or death.

What happens if I miss giving a dose of Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets?

If the interval between doses exceeds 30 days, the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable tablet must be given once a month, on or about the same day of the month. If treatment is delayed, whether by a few days or many, please contact your veterinarian, as immediate treatment with Tri-Heart Plus® chewable tablets and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.

What happens if I overdose my pet on Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets?

Contact your veterinarian immediately if accidental overdose occurs. To reduce the risk of accidental overdose in situations where more than one person may administer Tri-Heart Plus®, we suggest ticking off the date on a specially marked calendar or making some other note to indicate that the dose has been given. Make a habit of checking with the other pet caregivers in your household before giving any medications to your pet.

What should I avoid while giving Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets to my pet?

Do not administer Tri-Heart Plus® if your dog has not been tested for heartworms or if the test results are positive. This can cause severe reactions due to the presence of mature heartworms. Do not use Tri-Heart Plus® past its expiration date. The effectiveness of the medication may decrease, and it could be harmful to your dog. Some breeds, like Collies and other herding breeds, may have a genetic sensitivity to ivermectin. Avoid giving the medication to these breeds without consulting your veterinarian.

What other drugs will affect Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets?

Avoid giving your dog any other medications, especially those containing ivermectin or similar compounds, without consulting your veterinarian to prevent potential drug interactions.

Storage

Store at controlled room temperatures of 59° - 86°F. Protect product from light.

See more
How to use
plus minus

Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets Directions:

  • Give your dog one beef-flavored chewable Tri-Heart Plus® tablet on the same day each month during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active, at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. 
  • Remove only one chewable tablet at a time from the blister card. Because most dogs find Tri-Heart Plus® palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dry food or placed in the back of the dog’s mouth for forced swallowing.
  • Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.
  • The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog’s last exposure to mosquitoes.
  • The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms can be found in the table below.

Tip:

Incorporate the administration of Tri-Heart Plus® into a positive, routine activity that your dog enjoys, such as a monthly "spa day" or special treat time. For example, you can pair giving the tablet with a favorite treat, a fun grooming session, or a playtime ritual. This creates a positive association with taking the medication, making it easier for your dog to accept the tablet willingly each month. Additionally, by integrating the medication into a routine event, you're less likely to forget a dose, ensuring consistent heartworm and parasite prevention.

TRI-HEARTTri-Heart Plus® PLUS (ivermectin/pyrantel) Chewable Tablets Dosage

Dosage for Dogs & Puppies: (6+ weeks of age)
Weight Dosage Ivermectin Content Pyrantel Content Color Coding on Box
Up to 25 lbs Give 1 chewable every month 68 mcg 57 mg Blue Box
26-50 lbs Give 1 chewable every month 136 mcg 114 mg Green Box
51-100 lbs Give 1 chewable every month 272 mcg 227 mg Brown Box
Over 100 lbs Give combination of chewables based on weight See packaging See packaging See packaging
Dosage for Cats:
Cats
Do not use!
Dosage for Horses:
Horses
Do not use!
Ingredients
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Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets Ingredients:

Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets - Blue Box (Dogs up to 25 lbs):
Active Ingredients (per chewable tablet) Amount
Ivermectin 68 mcg
Pyrantel 57 mg
Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets - Green Box (Dogs 26-50 lbs):
Active Ingredients (per chewable tablet) Amount
Ivermectin 136 mcg
Pyrantel 114 mg
Tri-Heart Plus® (ivermectin/pyrantel) Chewable Tablets - Brown Box (Dogs 51-100 lbs):
Active Ingredients (per chewable tablet) Amount
Ivermectin 272 mcg
Pyrantel 227 mg
Q&A
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1. What Does Tri-Heart Plus Cover?
Answer
Tri-Heart Plus is a chewable tablet that is effective against heartworms and other hazardous parasites. Dogs can get infected with hookworms, roundworms, or heartworms at any point in life. Tri-Heart Plus is formulated with a tested combination of Ivermectin and Pyrantel to protect your dogs from these parasites. Tri-Heart Plus chewable tablets effectively prevent heartworms in dogs triggered by Dirofilaria immitis. The tablet is also effective in controlling and treating Ascarids and hookworms in canines and also six-week-old pups.
2. Are Triheart and Heartgard the Same?
Answer
It is surprising to know that both the top-line medicines are very similar when compared to their differences. The similarities are because of the two main ingredients in their making (Ivermectin and Pyrantel Pamoate). The similarity in ingredients makes them equally effective in preventing heartworms and treating roundworms and hookworms. Both Heartgard Plus and Tri-Heart Plus are available only on a veterinarian prescription. The dosage is also the same and given once every month. Both the medications are safe for breeding and pregnant dogs. The minimum age of puppies should be at least six weeks or more for administering both medicines. However, with all these similarities, the medications still have two key differences. The first difference is that Tri-Heart Plus is a beef-flavored chewable tablet, whereas Heartgard Plus is a soft beefy chew. The second difference is the rates; Tri-Heart Plus is much cheaper than Heartgard Plus, making the former a preferred choice.
3. Does Tri-Heart Plus Need to be Given with Food?
Answer
The effective dosage of Tri-Heart Plus is once every month or as per the dosage prescribed by your veterinarian. You can give the tablet directly or can even mix it with your dog’s routine food. It totally depends on how comfortable your dog is with taking these chewable tablets. However, the Tri-Heart Plus tablets come in beef flavor, and most dogs just eat it like some treat. We must ensure that the dosage is regular and once every month to protect your dog by eliminating any growing larva before it reaches your dog’s heart.
4. How Long is Tri-Heart Plus Good For?
Answer
Tri-Heart Plus is good for 30 days only. Hence, be sure to repeat the dosage immediately after a month. If you have missed a dose, give it as soon as you realize it and continue monthly. If the missed dose is over by two weeks, your dog must undergo microfilariae and antigen tests in 6 months. Repeat the tests in 6 months, as sometimes the results are not visible in the initial 6-month heartworm test. Because of its effectiveness of 30 days, you should set reminders for medication so that you do not miss any dose.
5. Does Tri-Heart Plus Prevent Tapeworms?
Answer
A simple answer to this can be a Yes. The monthly dosage of Tri-Heart Plus is capable of doing a lot more than preventing heartworm diseases. The medication can also control intestinal parasites like tapeworms, whipworms, hookworms, and roundworms. The only thing to remember is a regular dosage every 30 days and without skipping any dosage.
6. Can I Give My Dog Expired Tri-Heart Plus?
Answer
Any medication that includes Tri-heart Plus, which has reached its expiry date, should not be administered on pets. Tri-Heart Plus is only effective when used within its expiration date and when stored as mentioned on the medicine pack. The expiration date specifies that the active ingredients (Ivermectin and Pyrantel Pamoate) will not work effectively beyond the date.
7. What's the Difference between Tri-Heart Plus and Heartgard Plus?
Answer
There are two main differences between Tri-Heart Plus and Heartgard Plus. The first difference is that Tri-Heart Plus comes as a beef-flavored chewable tablet, whereas Heartgard Plus is a soft beefy chew. The second difference is the price; Tri-Heart Plus is much cheaper than Heartgard Plus, making the former a preferred choice.
8. What is the Difference between Trifexis and Tri-Heart Plus?
Answer
The main difference between the two medications is their active ingredients. While Tri-Heart Plus has Ivermectin and Pyrantel Pamoate, Trifexis contains Spinosad and Milbemycin Oxime. Other differences include the minimum dosage age, which is six weeks for Tri-Heart Plus, while it is eight weeks and 6 lbs of weight for Trifexis. Tri-Heart Plus is safe for breeding and pregnant dogs, but Trifexis is not yet proven for safety in pregnant, breeding, and lactating dogs. Trifexis provides extra protection from other hazardous parasites like fleas and whipworms, which cannot be said for Tri-Heart Plus.
9. Does Tri Heart Plus Require a Prescription?
Answer
Yes, it is mandatory to have a prescription to buy Tri-Heart Plus chewable tablets. You can consult your veterinarian about the same and get them prescribed for your pet dog.
10. When should I start heartworm prevention for my dog?
Answer
It is recommended to start heartworm prevention for your dog as early as possible, ideally before they are six months old. However, if your dog is older than six months and has not been on heartworm prevention, it is still necessary to start them on a preventative medication as soon as possible. Heartworm prevention medication is typically given monthly, and it is important to give it consistently throughout the year to ensure that your dog remains protected. Your veterinarian can recommend the most appropriate heartworm prevention medication for your dog based on age, weight, and other individual factors. In addition to giving your dog heartworm prevention medication, also have them tested for heartworms annually, even if they are on a preventative medication. This will ensure that any potential heartworm infection is detected early and can be treated before it becomes a serious health issue for your dog.
11. What are the signs of heartworms in dogs?
Answer
Heartworm disease in dogs can present with a variety of symptoms, which can vary depending on the severity of the infection. In the early stages of the disease, there may be no visible symptoms at all. A persistent cough is one of the most common signs of heartworm disease in dogs. The cough may be dry or may produce a small amount of phlegm. Dogs with heartworm disease may be less active than usual and may tire easily during exercise or play. Dogs with heartworm disease may lose their appetite or have difficulty eating. This can lead to weight loss and muscle wasting. As the heartworms grow and multiply in the lungs and heart, they can make it difficult for your dog to breathe. This can result in shortness of breath, rapid breathing, or wheezing. In advanced cases of heartworm disease, the heart and lungs may become so compromised that fluid accumulates in the abdomen. This can lead to a swollen belly or distended abdomen. Dogs with heartworm disease may have a dull, rough, or dry coat, which can be a sign of poor health. Some dogs may develop an allergic reaction to heartworms, which can cause skin irritation, hives, or other symptoms. In severe cases of heartworm disease, dogs may experience collapse or fainting. This can be a life-threatening emergency. In rare cases, heartworm disease can lead to bleeding problems, including nosebleeds, blood in the urine or stool, or excessive bleeding from wounds.
12. Is there natural heartworm prevention?
Answer
While there are some natural remedies that are sometimes suggested for heartworm prevention in dogs, it's important to note that there is no scientifically proven natural heartworm prevention method. Heartworm disease is a serious and potentially life-threatening condition, and the most effective way to prevent it is through the use of prescription heartworm prevention medication that has been tested and approved by the FDA. These medications work by killing the immature heartworms that are transmitted to dogs through mosquito bites, preventing them from developing into adult heartworms that can cause serious health problems. That being said, some people believe that adding garlic to a dog's diet can help to repel mosquitoes and reduce the risk of heartworm infection. However, garlic can actually be toxic to dogs in large amounts. Another natural remedy that is sometimes suggested for heartworm prevention in dogs is apple cider vinegar. Advocates claim that adding small amounts of apple cider vinegar to a dog's food or water can make their skin less attractive to mosquitoes, thus reducing the risk of heartworm infection. Some people suggest using neem oil as a natural mosquito repellent for dogs, which may help to reduce the risk of heartworm infection. However, neem oil can be toxic if ingested in large amounts, so it should be used with caution. Some herbal supplements, such as black walnut, wormwood, and clove, are sometimes recommended as natural heartworm preventatives for dogs. But none of these natural remedies have been scientifically proven to prevent heartworm disease in dogs, and relying solely on these methods may put your dog at risk of serious health problems.
13. Is heartworm treatment lifelong?
Answer
Heartworm treatment is a process used to eliminate adult heartworms that have already developed in a dog's body. The treatment typically involves a series of injections that are administered over several months, along with strict rest and exercise restrictions. Once the adult heartworms have been eliminated, it's necessary to continue with a preventative care plan to prevent re-infection. On the other hand, heartworm prevention refers to the regular use of prescription medication to prevent heartworms from developing in a dog's body in the first place. These medications are typically administered on a monthly basis and work by killing any immature heartworms that may have been transmitted to your dog through mosquito bites. While heartworm treatment is a temporary process that lasts several months, heartworm prevention is an ongoing process that requires regular administration of preventative medication.
14. How long can a dog go without heartworm pills?
Answer
Some monthly heartworm prevention medications have a "grace period" or "safety factor" of a few days to a couple of weeks, which means that missing a single dose may not immediately put your dog at risk of heartworm infection. However, missing even a single dose of heartworm prevention medication can increase the risk of heartworm infection, and a regular, consistent administration of preventative medication is the best way to ensure that your dog remains healthy and heartworm-free. If you do miss a dose of heartworm prevention medication, it's best to contact your veterinarian for advice on how to proceed.
15. What ingredient kills heartworms?
Answer
The active ingredient that kills heartworms in most prescription heartworm prevention medications is called ivermectin. Ivermectin works by targeting the immature heartworms (microfilariae) that are transmitted to dogs through mosquito bites, preventing them from developing into adult heartworms that can cause serious health problems. Other prescription heartworm prevention medications may contain different active ingredients, such as milbemycin oxime, selamectin, or moxidectin, which also work to prevent heartworm infection by targeting immature heartworms. You should note that prescription heartworm prevention medications, including those containing ivermectin, milbemycin oxime, selamectin, or moxidectin, are designed to prevent the development of heartworms in their early stages when they are still immature microfilariae. These medications do not work on adult heartworms, which have already developed in a dog's body. To eliminate adult heartworms, a different treatment process involving a series of injections over several months is required. That's why it's crucial to follow your veterinarian's recommended preventative care plan and schedule regular check-ups to ensure that your dog remains healthy and heartworm-free.
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Kathleen
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Cost conscious
I used to buy Heartgard, but the Tri-Heart Plus is such a better bargain. We can all use a bargain.
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Cynthia
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Necessary for Health and Longevity
I purchase this brand as it�s much less expensive than the name brand; however, the ingredients are basically the same. My puppy Max eats the tablet without any hesitation. Anywhere mosquitoes fly - this preventative is required.
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